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<p>Synthesis, characterization, cytotoxicity evaluation and physicochemical properties of some novel <em>N</em><sup>4</sup>-substituted aminobenzenesulfonamides</p><br />

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Title Statement <p>Synthesis, characterization, cytotoxicity evaluation and physicochemical properties of some novel <em>N</em><sup>4</sup>-substituted aminobenzenesulfonamides</p><br />
 
Added Entry - Uncontrolled Name Durgun, Mustafa ; Department of Chemistry, Faculty of Arts and Sciences, Harran University, Sanliurfa, 63290, Turkey
Turkoglu, Seda ; Department of Chemistry, Faculty of Arts and Sciences, Harran University, Sanliurfa, 63290, Turkey
Sonmez, Hasan ; Department of Chemistry, Faculty of Arts and Sciences, Harran University, Sanliurfa, 63290, Turkey
Zengin, Gulay ; Department of Chemistry, Faculty of Arts and Sciences, Gaziantep University, Gaziantep, 27310, Turkey
Zengin, Huseyin ; Department of Chemistry, Faculty of Arts and Sciences, Gaziantep University, Gaziantep, 27310, Turkey
Koyuncu, Ismail ; Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, 63300, Turkey
Kuru, Ali ; Department of Chemistry, Faculty of Arts and Sciences, Sakarya University, Sakarya, 54187, Turkey
Harran University (Project No. HUBAK 12059 and 12167), Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 115Z681), Gaziantep University (Project No. GÜ FEF.11.07)
 
Uncontrolled Index Term Synthesis, N4-substituted aminobenzenesulfonamides, cytotoxicity, photoluminescence, physicochemical properties
 
Summary, etc. <p>Several <em>N</em><sup>4</sup>-substituted aminobenzenesulfonamides derivatives have been synthesized and structural analyses have been carried out using FT-IR, UV-Vis, <sup>1</sup>H and <sup>13</sup>C NMR, LC-MS-MS and elemental analyses. Photoluminescence and physicochemical properties<strong> </strong>have also been conducted. Two 4-aminobenzenesulfonamides have been treated with 2-bromopropionyl bromide in pyridine to give their respective bromo substituted aminobenzenesulfonamides as intermediates. Subsequent reactions with morpholino-, thiomorpholino- and piperazine amines have yielded novel aminobenzenesulfonamide derivatives. As it is well known that CA IX and CA XII enzymes play an active role in attacking various cancerous conditions, studies presented in this study target these enzymes with <em>i</em><em>n vitro</em> cytotoxicity studies being performed on the compounds synthesized. The target compounds have been found to be active against some cancerous cells, with mimimal effects on normal cells. The physicochemical data reveal interesting synergistic effects controlling cytotoxicities, where the lipophilicity and polarity combinations play important roles on the eventual observed cytotoxicities. Further, the electronegativity and availability of the electrons of the heteroatoms of the synthesized compounds appear to have an effect on cancer cell cytotoxicities.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-07-29 15:26:04
 
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http://op.niscair.res.in/index.php/IJCB/article/view/43707
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 6 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/43707/465539352
http://op.niscair.res.in/index.php/IJCB/article/download/43707/465539353
 
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