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An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents
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| Creator |
Gullapelli, Kumaraswamy
Maroju, Ravichandar Merugu, Ramchander |
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| Subject |
Benzimidazole
Docking study Isoxazole Pyrazole Synthesis |
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| Description |
343-350
The present study is the synthesis of new heterocyclic moieties like pyrazole, isoxazole and thiazole containing benzimidazole nucleus. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine. The newly synthesised compounds were screened for their in vitro anti-inflammatory activity and demonstrated excellent to moderate activity and molecular docking study reports are supporting anti-inflammatory activity showed high inhibition constant and binding energy. The structures of synthesised compounds were characterized by IR, 1HNMR, Mass spectroscopic methods. |
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| Date |
2021-08-05T06:01:37Z
2021-08-05T06:01:37Z 2021-05 |
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| Identifier |
0975-0991 (Online); 0971-457X (Print)
http://nopr.niscair.res.in/handle/123456789/57837 |
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| Publisher |
NIScPR-CSIR, India
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| Source |
IJCT Vol.28(3) [May 2021]
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