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Withania somnifera ameliorates nandrolone-decanoate-induced brain damage in rats by inhibiting cell death, prodynorphin mRNA expression and acetylcholinesterase activity

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Title Withania somnifera ameliorates nandrolone-decanoate-induced brain damage in rats by inhibiting cell death, prodynorphin mRNA expression and acetylcholinesterase activity
 
Creator Vasavan, Smitha S
Sivanesan, Senthilkumar
Jagadesan, Vijayakumar
 
Subject Acetylcholinesterase
Anabolic-androgenic steroids
Nandrolone decanoate
Necrosis, Striatum
Withania somnifera
 
Description 685-693
The misuse of anabolic-androgenic steroids by athletes and non-athletes causes harmful effects on the central nervous
system. In Ayurvedic medicine, Withania somnifera (WS) as an herbal drug has been reported for several functions
including adaptogenic, anticonvulsant, cytoprotective and antioxidant. The present study investigated the neuroprotective
functions of WS (100, 200 and 400 mg/kg body weight) in nandrolone decanoate (ND)-induced (16 mg/kg body weight)
brain injury in male Wistar rats. ND was injected intramuscularly twice weekly for 4 weeks. The water emulsion of WS root
powder was administered orally once daily for 30 days to ND-treated rats. At the end of the experiment, anxiety-like
behaviour was assessed in rats using the elevated plus maze. Haematoxylin-and-eosin-stained coronal sections of the parietal
cortex and hippocampus of ND rats showed severe alterations in brain histology compared with control rats.
Acetylcholinesterase (AChE) activity in the striatum and prodynorphin gene expression in the hippocampus was
significantly elevated in the ND group compared with the control group. Treating ND induced rats with various doses of
WS significantly reversed the brain damage, anxiety behaviour, increased striatal AChE activity and reduced prodynorphin
gene expression in the hippocampus. In conclusion, WS extract can be used as a neuroprotective agent to reduce the effects
of anabolic steroids.
 
Date 2021-08-06T07:25:04Z
2021-08-06T07:25:04Z
2021-07
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/57884
 
Language en
 
Relation Int Cl.21: A61K 9/00, A61K 36/81, A61K 36/185, A61K 38/00, A61K 39/395, A61K 45/06
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.20(3) [July 2021]