Record Details

Sub chronic oral toxicity study of Janma Ghunti Honey in Wistar rats

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Sub chronic oral toxicity study of Janma Ghunti Honey in Wistar rats
 
Creator Kumar, S
Singh, P
Rai, R K
Gupta, A
Sastry, J L N
 
Subject Janma Ghunti Honey
Sub chronic toxicity
Wistar rats
 
Description 660-670
The present study was conducted to evaluate the safety profile of Janma Ghunti Honey in Wistar rats on oral administration for 28 consecutive days. Animals were randomized on the basis of body weight into 6 groups. Three groups received test item (TI) at three different dose levels (3 mL/k g, 6 mL/kg and 12 mL/kg body weight). One group served as high dose satellite reversal group (12 mL/kg). One group each served as the control and satellite control group. Animals were observed for clinical signs of toxicity and mortality at least once daily. Animals from satellite groups were observed for further 14 days without treatment to evaluate delayed occurrence or reversibility of any signs/toxicity. At the end of the study, animals were studied through clinical pathology and necropsy examination. No treatment related mortality was observed in any group. Except in female low dose and female high dose satellite groups, all the treated groups exhibited weight gain and no statistically significant alterations were observed. No TI related toxicity was found on hematological investigation, blood biochemistry parameters and absolute and relative organ weights among treated groups. 'No Observed Adverse Effect Level' of TI in male and female Wistar rats was found to be above 12 mL/kg body weight.
 
Date 2021-08-06T08:57:21Z
2021-08-06T08:57:21Z
2021-07
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/57887
 
Language en
 
Relation Int Cl.21: A61K 9/00, A61K 35/644, A61K 36/00, A61K 45/06, A62D 3/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.20(3) [July 2021]