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<strong>An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents</strong>

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Title Statement <strong>An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents</strong>
 
Added Entry - Uncontrolled Name GULLAPELLI, KUMARASWAMY ; Mahatma Gandhi Institute of Technology Jawaharlal Nehru Technological University Hyderabad
Maroju, Ravichandar ; Mahatma Gandhi Institute of Technology Jawaharlal Nehru Technological University Hyderabad
Merugu, Ramchandar ; Dept.of Biochemistry, Mahatma Gandhi University, Nalgonda -Telangana 508254
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Uncontrolled Index Term Benzimidazole;Docking study;Isoxazole;Pyrazole;Synthesis
 
Summary, etc. <p><span>The present study is the synthesis of new heterocyclic moieties like pyrazole, isoxazole and thiazole containing benzimidazole nucleus. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine. The newly synthesised compounds were screened for their in vitro anti-inflammatory activity and demonstrated excellent to moderate activity and molecular docking study reports are supporting anti-inflammatory activity showed high inhibition constant and binding energy. The structures of synthesised compounds were characterized by IR, 1HNMR, Mass spectroscopic methods.</span></p>
 
Publication, Distribution, Etc. Indian Journal of Chemical Technology (IJCT)
2021-08-17 17:06:45
 
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http://op.niscair.res.in/index.php/IJCT/article/view/39350
 
Data Source Entry Indian Journal of Chemical Technology (IJCT); ##issue.vol## 28, ##issue.no## 3 (2021): Indian Journal of Chemical Technology
 
Language Note en