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Clathrolides A–B: previously undescribed macrocylic lactones from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as potential antihypertensive leads attenuating angiotensin converting enzyme

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Relation https://eprints.cmfri.org.in/13545/
https://link.springer.com/article/10.1007%2Fs00044-021-02743-4
 
Title Clathrolides A–B: previously undescribed macrocylic lactones from
marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as
potential antihypertensive leads attenuating angiotensin converting
enzyme
 
Creator Francis, Prima
Chakraborty, Kajal
 
Subject Bioactive compounds
Biochemistry
Fish Biotechnology
 
Description Biochemical investigation of bioactive compounds from the marine demospongiae Clathria (Thalysias) vulpina (Lamarck,
1814) (family Microcionidae) resulted in the isolation of two previously undescribed 22-membered macrocyclic lactone
derivatives clathrolide A and B from its organic extract. Structural elucidation of the compounds were carried out using
spectroscopic analysis. Clathrolide A exhibited greater antihypertensive (IC50 0.44 ± 0.02 mM), anti-inflammatory (IC50
0.74 ± 0.04 mM), anti-hyperglycemic (IC50 0.85 ± 0.01 mM), and antioxidant (IC50 0.70 ± 0.03 mM) activities compared to
clathrolide B. Among various bioactivities, such as antihypertensive, anti-inflammatory, anti-hyperglycemic, and antioxidant
properties, angiotensin converting enzyme attenuation potential of clathrolide A was found to be significantly greater, and
comparable with the standard antihypertensive drug, captopril (IC50 0.36 ± 0.03 mM). Higher electronic properties
(topological polar surface area 133.52) along with comparatively lesser docking score and binding energy of clathrolide
A with the aminoacyl residues of angiotensin-I converting enzyme (−12.38 and −12.91 kcal/mol, respectively) recognized its
prospective inhibitory property against the enzyme catalyzing the rate-limiting step to form the vasoconstrictor angiotensin-II
 
Publisher Springer
 
Date 2022-03-08
 
Type Article
NonPeerReviewed
 
Format text
 
Language en
 
Identifier https://eprints.cmfri.org.in/13545/1/Medicinal%20Chemistry%20Research_2021_Chakraborty%20Kajal%20Clathria%20%28Thalysias%29%20vulpina%20%28Lamarck%2C%201814%29.pdf
Francis, Prima and Chakraborty, Kajal (2022) Clathrolides A–B: previously undescribed macrocylic lactones from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as potential antihypertensive leads attenuating angiotensin converting enzyme. Medicinal Chemistry Research, 30. pp. 1438-1451.