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Prominent nephroprotective effect of methanolic Broccoli <i>(Brassica olaracea var. italica)</i> extract on oxidative lead damage in mice kidney: Biochemical parameters and pathological changes

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Title Prominent nephroprotective effect of methanolic Broccoli (Brassica olaracea var. italica) extract on oxidative lead damage in mice kidney: Biochemical parameters and pathological changes
 
Creator Raeeszadeh, Mahdieh
Zobeiri, Ashkan
Khademi, Nadia
Mortazavi, Pejman
 
Subject Heavy metal pollution
Kidney
Oxidative stress
Reactive oxygen spices (ROS)
Renal damage
 
Description 626-632
Exposure to Lead causes oxidative stress and thereby reduces the antioxidant capacity of the cells. Broccoli is a well-known important source of antioxidant and mineral compounds. Here, we investigated the antioxidant potency of methanolic extract of broccoli in preventing renal toxicity. NMRI mice in the control group were given normal drinking water and the T1 experimental group received 500 ppm lead acetate in drinking water. The T2, T3, and T4 experimental groups received 300, 400 and 500 mg/kg of broccoli methanolic extract, respectively. On the last day, biochemical parameters and oxidative stress were measured in the kidney. Kidney tissue was used for preparation of sections and pathological studies. The highest concentrations of biochemical parameters in T1 showed a significant difference in comparison with the control and T4 groups (P
 
Date 2021-09-14T06:35:38Z
2021-09-14T06:35:38Z
2021-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58100
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.59(09) [September 2021]