Record Details

Interaction studies of diglycine with aqueous solutions of sulphathiazole drug at different temperatures

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Interaction studies of diglycine with aqueous solutions of sulphathiazole drug at different temperatures
 
Creator Pal, Amalendu
Soni, Surbhi
 
Subject Diglycine
Sulphathiazole
Apparent molar volume
Apparent molar isentropic compression
 
Description 1164-1171
The interactions of diglycine with sulphathiazole drug as a function of temperatures have been studied using volumetric
and acoustic parameters. Densities and speeds of sound of diglycine in (0.001, 0.002, 0.005 and 0.010) mol·kg-1 aqueous
solutions of sulphathiazole drug have been measured at five different temperatures of (288.15, 293.15, 298.15, 303.15 and
308.15) K under 0.1 MPa pressure. From density data, the apparent molar volume, the partial molar volume and the standard
partial molar volume of transfer for glycine from water to aqueous sulphathiazole solutions have been calculated. Partial
molar isentropic compression and partial molar isentropic compression of transfer have been calculated from the speed of
sound data. Transfer parameters by using cosphere overlap model have been explained on the basis of ionic-hydrophilic,
hydrophilic-hydrophilic, hydrophilic-hydrophobic and hydrophobic-hydrophobic group interactions. To draw the conclusion
from the volumetric and acoustic data, limiting apparent molar expansion as well as the hydration numbers have been
studied. The calculated values of thermal expansion coefficient have small and positive values. All of these derived or
calculated parameters are explained to understand the solvation behaviour and various types of interactions born in the
ternary solutions of (dipeptide + drug + water) due to change in structure. We have also attempted to examine the
temperature and concentration dependence of such interactions.
 
Date 2021-09-17T07:04:20Z
2021-09-17T07:04:20Z
2021-09
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/58110
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-A Vol.60A(09) [September 2021]