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<p><strong>Synthesis, Spectral Characterisation and Pharmacological Studies on Co(II), Ni(II), Cu(II) and Zn(II) Bis-Schiff Base Complexes Derived From 4-hydroxybenzohydrazide</strong></p>

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Title Statement <p><strong>Synthesis, Spectral Characterisation and Pharmacological Studies on Co(II), Ni(II), Cu(II) and Zn(II) Bis-Schiff Base Complexes Derived From 4-hydroxybenzohydrazide</strong></p>
 
Added Entry - Uncontrolled Name Priya, Palanisamy ; Kandaswami Kandar's College
 
Uncontrolled Index Term Bio-inorganic chemistry
Bis-Schiff base, docking, DNA binding and cleavage, antioxidant, anticancer activity
 
Summary, etc. <p>The transition metal(II) chelates were prepared by the reactions of bis-Schiff base ligands derived from 4-hydroxy benzohydrazide and isophthalaldehyde / o-phthaldehyde in 1:1 metal to ligand ratio. The formed ligands and their metal complexes have been investigated by the following spectroscopic tools i.e, elemental analysis, FT-IR spectra, molar conductance, <sup>1</sup>H NMR, ESI-mass, electronic spectra, magnetic moments, ESR and thermal analyses. The low molar conductance values give the non- electrolytic nature of the metal(II) chelates. From that the spectroscopic observations of complexes having the molecular formula [M(L<sub>n</sub>)<sub>2</sub>Cl<sub>2</sub>] (where M= Co(II), Ni(II), Cu(II) and Zn(II), n=1and 2) and act as tetradentate N<sub>2</sub>O<sub>2 </sub>donor sites of ligands. The docking results predicts that the protein with ligands having good interaction energy. All formed complexes have efficient antibacterial activity than ligand of tested pathogens. The mode of binding interaction of ct-DNA and Cu(II) complexes gives the intercalative binding with hypochromism shifts using electronic titrations method. In electrophoresis, cleavages of PUC18DNA to cleave effectively with Cu(II) complexes in the presence of hydroxyl radicals. The antioxidant assay of DPPH radical scavenging activity of tested compounds shows good results, when compared to ascorbic acid as standard. The anticancer MTT assay of Cu(II) complexes tested against MCF-7 cancerous cells gives the promising therapeutic activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-09-22 10:50:13
 
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http://op.niscair.res.in/index.php/IJCA/article/view/46073
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 7 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/46073/465547930
http://op.niscair.res.in/index.php/IJCA/article/download/46073/465548159
 
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