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<p><strong>Synthesis, Characterization and Biological Evaluation of heterocyclic triazole derived Schiff base ligands comprising Mn(II) complexes: Implications of their DNA/Protein Binding Docking and Anticancer Activity Studies</strong><strong></strong></p>

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Title Statement <p><strong>Synthesis, Characterization and Biological Evaluation of heterocyclic triazole derived Schiff base ligands comprising Mn(II) complexes: Implications of their DNA/Protein Binding Docking and Anticancer Activity Studies</strong><strong></strong></p>
 
Added Entry - Uncontrolled Name Dr, Bhuvanaeshwari
Sangeetha, T V; Assistant Profesor
Mohanapriya, S ; Senior Research Associate CSIR-CECRI
CSIR
 
Uncontrolled Index Term Synthetic and structural inorganic chemistry; Bio-inorganic chemistry;
Heterocyclic Schiff base, 1H-1,2,4-triazol-3-amine ligands, Mn(II) complexes, Inorganic complex, Antimicrobial studies, Molecular Docking.
 
Summary, etc. <p>Schiff base ligands comprising heterocyclic moieties deserve distinct consideration because of their excellent chemotherapeutic and antioxidant properties as biologically active agents. In present investigation, two novel heterocyclic triazole derived Schiff base ligands were synthesized using 3-chlorobenzaldehyde (L1), 4-methoxybenzaldehyde (L2) with 1H-1,2,4-triazol-3-amine backbone that are biologically active.  Mn(II) complexes were synthesized by combing  ligands in 1:2 molar ratio (Metal : Ligand), their structure and bonding nature were recognised by respective physical, spectral and analytical data. The ligands (L1 &amp; L2) and their metal complexes were characterized by elemental analyses, electronic spectra (UV-Vis), Fourier Transform Infrared Spectrometer FT-IR, Proton <sup>1</sup>H and Carbon <sup>13</sup>C NMR and EPR spectrum. Antimicrobial activity of the synthesized L1, L2 and their metal complexes were tested against <em>Bacillus subtilis</em> (<a title="Gram-positive" href="https://en.wikipedia.org/wiki/Gram-positive">Gram-positive</a>, <a title="Catalase" href="https://en.wikipedia.org/wiki/Catalase">catalase</a>-positive <a title="Bacterium" href="https://en.wikipedia.org/wiki/Bacterium">bacterium</a>) as well as Fungi namely <em>Phylium Aphanidematum, Macrophomina phasiolina, Fusarium oxysporum</em>. Both the ligands and metal complexes exhibit excellent antimicrobial activity under low inhibitory concentration such MIC ≤ 250 μg/ml. Upon co-ordination, antimicrobial properties has been enhanced by 21%. The anticancer activity of the synthesized complex investigated against human tumor cell lines (Breast cancer MCF-7 cells) demonstrated that L1M complex displays potent inhibition against MCF-7. Outcome of research results demonstrate that these compounds are potential candidates for the next step of drugs invention towards breast cancer treatment. Using this molecular docking study we can predict the complex–biomolecular interaction and it plays vital role in the drug discovery and also it is a step by step process which used to place synthesised compounds into the binding sites of the DNA molecule. Further, Molecular DNA docking results demonstrated encouraging responses, thereby opening up new avenues for the application of the synthesized inorganic triazole derivative complexes as leads for the development of novel anti-cancer drugs.</p> <p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-09-22 10:23:28
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/42849
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 6 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535959
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535962
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535963
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535964
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535965
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535973
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535975
http://op.niscair.res.in/index.php/IJCA/article/download/42849/465535976
 
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