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<p>Investigation on bindings of a binaphthoquinone derivative with serum albumin proteins by fluorescence spectroscopy</p>

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Title Statement <p>Investigation on bindings of a binaphthoquinone derivative with serum albumin proteins by fluorescence spectroscopy</p>
 
Added Entry - Uncontrolled Name Jali, Bigyan Ranjan; Veer Surendra Sai University of Technology Burla
DST, India by EMEQ project (No.-EEQ/2019/000091).
 
Uncontrolled Index Term Spectroscopy, analytical chemistry, Thermodynamics
Quinone, BSA, HSA, fluorescence, docking
 
Summary, etc. <p class="02PaperAuthors">Binding of a binaphthoquinone derivative namely, 5a,5b-dimethyldibenzo[b,h]biphenylene-5,6,11,12(5aH,5bH,11aH,11bH)-tetraone (L, C<sub>22</sub>H<sub>16</sub>O<sub>4</sub>)  with bovine serum albumin (BSA) and human serum albumin (HSA) have been examined by using fluorescence spectroscopy. The fluorescence emission of the L is quenched upon addition of L to a solution of  BSA or that of HSA, but the BSA has shown a higher affinity towards L over  the HSA protein. A molecular docking study is also performed to suggest the sites of BSA  for weak interactions to bind the L. The docking analysis,  has revealed the N-H···O  hydrogen bonds of L with different  amino acid residues. The L is located at about 7.7Å  away from the Trp-213 which is the fluorescent unit of the BSA suggesting the role of environment of the tryptophan residue to be an important to have changed the emission intensities.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-09-22 10:23:28
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/43630
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 6 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538928
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538929
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538930
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538931
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538932
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538933
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538934
http://op.niscair.res.in/index.php/IJCA/article/download/43630/465538935
 
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