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Synthesis of isomeric naphthofuranyl coumarins as anti-inflammatory and analgesic agents

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Field Value
 
Title Synthesis of isomeric naphthofuranyl coumarins as anti-inflammatory and analgesic agents
 
Creator Yaragatti, Naazneen
Khanapurmath, Netravati
Kulkarni, Manohar V
 
Subject Naphthofuranyl
coumarin
anti-inflammatory
analgesic activity
angular/linear naphthofuranyl coumarins
 
Description 1007-1013
A two-step synthetic scheme has been employed for the synthesis of 4-naphtho [2, 1-b] furan-2-yl-chromen-2-ones/4-(3-alkoxy-naphtho-[2,3-b]furan-2-yl)-chromen-2-ones(angular/linear naphthofuranyl coumarins). The reactions have been monitored by TLC and structures of the intermediates and the target compounds have been ascertained by IR, NMR and mass spectral data. Both the isomeric naphthofuranyl coumarins have been found to exhibit anti-inflammatory activity comparable to asprin but when tested for analgesic activity, angularly fused naphthofuranyl coumarins show better activity comparable to asprin whereas linear naphthofuranyl coumarins are less active.
 
Date 2021-09-29T07:17:55Z
2021-09-29T07:17:55Z
2021-07
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58177
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(07) [July 2021]