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Design and synthesis of new quinoline hybrid derivatives and their antimicrobial, antimalarial and antitubercular activities

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Title Design and synthesis of new quinoline hybrid derivatives and their antimicrobial, antimalarial and antitubercular activities
 
Creator Lagdhir, Mohit
Pandya, Chintan
Pandya, Aditee
Vekariya, Rajesh H
Rajani, Dhanji P
 
Subject Molecular hybridization
pharmacophore
quinoline
structural activity relationship (SAR)
antimicrobial activity
antimalarial activity
antitubercular activity
 
Description 986-998
All the molecules have been designed on the basis of previously reported active pharmacophores via molecular
hybridization. A convenient protocol for the preparation of N-((2-(piperazin-1-yl) quinolin-3-yl)methyl)aniline derivatives via
mutli-step synthesis has been described. Spectral analysis using Mass, 1H and 13C NMR spectral techniques have been studied
in order to confirm the structure of synthesized end molecules. All synthesized compounds have been screened for in vitro
antimicrobial, antimalarial and antitubercular activities. Structural activity relationship study (SAR) have also been discussed.
Interestingly, target molecules are found to show good to excellent antibacterial, antifungal and antimalarial potency.
 
Date 2021-09-29T07:25:49Z
2021-09-29T07:25:49Z
2021-07
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58179
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(07) [July 2021]