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An efficient synthesis of Vildagliptin intermediates

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Field Value
 
Title An efficient synthesis of Vildagliptin intermediates
 
Creator Li, Yufei
Jiang, Lan
Zhang, Li
Wang, Jingyu
Xiang, Peng
Pan, Junyi
Hu, Xiangnan
 
Subject Vildagliptin
intermediate
3-amino-1-adamantane alcohol
(S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile
 
Description 1128-1131
Efficient and high yielding methods for the preparation of vildagliptin 1 intermediate of (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile 2 and 3-amino-1-adamantane alcohol 3 respectively have been described. (S)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile 2 has been synthesized from L-proline 2a via chloroacetyl chloride, performed with acetonitrile in the presence of sulfuric acid via one-pot reactions. 3-Amino-1-adamantane alcohol 3 has been prepared from amantadine hydrochloride via oxidation by sulfuric acid/nitric acid and boric acid as catalyst, and has been subjected to ethanol extraction. The overall yield is about 95%.
 
Date 2021-09-29T09:45:02Z
2021-09-29T09:45:02Z
2021-08
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58185
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(08) [August 2021]