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Synthesis of bis chalcones and transformation into bis heterocyclic compounds with expected antimicrobial activity

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Title Synthesis of bis chalcones and transformation into bis heterocyclic compounds with expected antimicrobial activity
 
Creator Ghoneim, Amira A
Elbargisy, Rehab M
Manoer, Afaf
 
Subject Synthesis
bis chalcones
heterocyclic
ethylcyanoacetate
cyanopyridine
 
Description 1272-1278
One-pot synthesis of novel derivatives of bis-chalcones has been achieved by condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gives compounds 4a,b. This, when reacted with ethyl cyanoacetate in presence of ammonium acetate gives the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b has been cyclized to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products have been characterized by IR, 1H and 13C NMR, and elemental analysis. The newly synthesised compounds have been screened for anti-bacterial activity
 
Date 2021-09-29T10:22:24Z
2021-09-29T10:22:24Z
2021-09
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58192
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(09) [September 2021]