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An efficient synthesis of 1, 4- disubstituted-3-methyl pyrazolo [4, 3-e]-pyrido [1, 2-a] pyrimidines via Michael addition and cycloelimination reactions

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Title An efficient synthesis of 1, 4- disubstituted-3-methyl pyrazolo [4, 3-e]-pyrido [1, 2-a] pyrimidines via Michael addition and cycloelimination reactions
 
Creator Tiwari, Shailendra
Ahamd, Akeel
 
Subject 4-Disubstitutedaroyl/aroyloxy methyl
Schiff base
pyrazolo
pyrido [1,2-a]pyrimidine
antimicrobial
antibacterial activity
antifungal activity
 
Description 1258-1263
A new series of novel 1, 4-disubstituted-3-methyl pyrazolo [4,3-e]-pyrido [1,2-a] pyrimidines have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MBC) and minimum fungicidal concentration (MFC) have been determined for the test compounds as well as for reference standards. Compounds 3d, 3e, 3f, 3h have shown good antibacterial activity whereas compounds 3a, 3b, 3c, 3g have displayed better antifungal activity.
 
Date 2021-09-29T10:32:20Z
2021-09-29T10:32:20Z
2021-09
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58194
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(09) [September 2021]