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Synthesis and screening for antioxidant and cytotoxic activities of novel 2-thioxo-benzo[f]chromeno[2,3-d]pyrimidin-4-ones derived by cetylpyridinium chloride catalyzed multicomponent reactions in aqueous micellar media

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Title Synthesis and screening for antioxidant and cytotoxic activities of novel 2-thioxo-benzo[f]chromeno[2,3-d]pyrimidin-4-ones derived by cetylpyridinium chloride catalyzed multicomponent reactions in aqueous micellar media
 
Creator Ahanthem, Dini
Thiyam, Medhabati
Haobam, Reena
Laitonjam, Warjeet S
 
Subject Cetylpyridinium chloride
benzochromenopyrimidinones
multicomponent reactions
antioxidant
cytotoxicity
 
Description 1243-1257
The cetylpyridinium chloride (CPC) has been used as micellar catalyst in three-component one-pot reaction involving thiobarbituric acids, aromatic aldehydes and β-napthol for synthesizing the novel 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivatives in aqueous media. These 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivativeshave been screened for antioxidant and cytotoxic activities. It has been found that 2-thioxo-5-(4-nitrophenyl)-benzo[f]chromeno[2,3-d]pyrimidin-4-one (4a) has shown highest scavenging activity value to reduce DPPH free radicals,which may be due to the presence of nitro group at para-position. Three compounds, 4a, 4b and 4o show significant in vitroantitumor activity. The study of the antioxidant and cytotoxic activities reveal that all the compounds show moderate togood activity indicating that the presence of thiouriedo linkage in the pyrimidine nucleus and the chromeno group attachedto pyrimidene moiety are responsible for these activities.
 
Date 2021-09-29T10:36:03Z
2021-09-29T10:36:03Z
2021-09
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58195
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(09) [September 2021]