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Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water

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Title Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water
 
Creator Thiyam, Medhabati
Thaodem, Ranjana Devi
Laitonjam, Warjeet Singh
 
Subject Synthesis
arylbenzo[4,5]thiazolopyrimido[5,4-d]pyrimidin-4-ones
metal-proline
aqueous medium
 
Description 1230-1242
A facile and highly efficient one pot multi-component reaction for the synthesis of 2-thio-5-arylbenzo [4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one derivatives 4 under aqueous medium has been developed. The reaction takes place by condensation of thiobarbituric acids 1, 2-aminobenzothiazole 2 and aldehydes 3 using metal-proline catalyzed domino Knoevenagel, Michael and intramolecular cyclization approach.
 
Date 2021-09-29T10:38:44Z
2021-09-29T10:38:44Z
2021-09
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58196
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(09) [September 2021]