Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water
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Title |
Synthesis of biologically active 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one derivatives catalyzed by metal proline in water
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Creator |
Thiyam, Medhabati
Thaodem, Ranjana Devi Laitonjam, Warjeet Singh |
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Subject |
Synthesis
arylbenzo[4,5]thiazolopyrimido[5,4-d]pyrimidin-4-ones metal-proline aqueous medium |
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Description |
1230-1242
A facile and highly efficient one pot multi-component reaction for the synthesis of 2-thio-5-arylbenzo [4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one derivatives 4 under aqueous medium has been developed. The reaction takes place by condensation of thiobarbituric acids 1, 2-aminobenzothiazole 2 and aldehydes 3 using metal-proline catalyzed domino Knoevenagel, Michael and intramolecular cyclization approach. |
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Date |
2021-09-29T10:38:44Z
2021-09-29T10:38:44Z 2021-09 |
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Type |
Article
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Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58196 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC-B Vol.60B(09) [September 2021]
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