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Preparation, characterization, antibacterial, antifungal and antioxidant activities of novel pyrazole-thiazole derivatives

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Title Preparation, characterization, antibacterial, antifungal and antioxidant activities of novel pyrazole-thiazole derivatives
 
Creator Shah, Purvesh J
 
Subject Pyrazole-thiazole
spectral studies
antimicrobial activity
antioxidant activity
 
Description 1223-1229
In the present study, 4-((1H-benzo[d][1,2,3]triazol-1-yl)methylamino)-N-(2,3-diphenyl-5-aryl-3,3a-dihydro-2H-pyrazolo
[3,4-d]thiazol-6(5H)-yl)benzamide IVa-h has been synthesized by reaction between various 4-((1H-benzo[d][1,2,3]triazol-
1-yl) methylamino)-N-(5-arylidene-4-oxo-2-phenylthiazolidin-3-yl)benzamides IIa-h with phenyl hydrazine. The reaction
of 4-((1H-benzo[d][1,2,3]triazol-1-yl)methylamino)-N-(4-oxo-2-aryl thiazolidin -3-yl) benzamide Ia-h with benzaldehyde
yields IIa-h. All the newly prepared compounds have been characterized by various spectroscopic techniques and screened
for their in vitro antimicrobial and antioxidant activity. The investigation of anti microbial screening data reveals that most
of the compounds tested have demonstrated moderate to good activity. Most of the heterocyclic derivatives bearing two
hydroxyl groups on the phenyl ring show excellent antioxidant activity in comparison with ascorbic acid.
 
Date 2021-09-29T10:40:17Z
2021-09-29T10:40:17Z
2021-09
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58197
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(09) [September 2021]