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Expression of Twist 1 in bone marrow and extramedullary lesions of patients with myeloma and its prognostic significance

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Title Expression of Twist 1 in bone marrow and extramedullary lesions of patients with myeloma and its prognostic significance
 
Creator Han, Mei
Zhang, Liyan
Liu, Jiao
Liu, Yang
Cai, Ying
Hu, Bing
Tian, Na
Leng, Bing
Li, Zunyan
 
Subject Multiple Myeloma
Plasma cells
 
Description 722-726
In patients with multiple myeloma (MM) extramedullary (EM) lesions could be a possible indicator of poor prognosis.
Twist 1, an EMT related transcription factor, is known to play an important role in embryonic development and also in the
process of tumor cell proliferation, apoptosis, metastasis etc. The Twist 1 protein expression hence has prognostic
significance in MM. This study investigates expression of Twist-1 in MM patients with extramedullary lesions and its
relationship with clinicopathological data and prognosis, so as to elucidate the clinical significance of Twist-1 expression.
Patients with MM complicated with EM lesions were selected retrospectively, including 35 cases in the bone marrow group
(MM complicated with extramedullary lesions) and 80 cases in the extramedullary group (MM combined with
extramedullary lesions). The expression of Twist 1 protein was detected by immunohistochemistry. The relationship
between Twist 1 protein expression and general clinicopathological data was analyzed by statistics. The relationship
between Twist 1 protein expression and prognosis was analyzed by COX single factor and multivariate regression analysis.
Immunohistochemical staining showed that the expression level of Twist-1 protein in the nucleus of myeloma cells in the
extramedullary group was significantly higher than that of the bone marrow group. However, in the cytoplasm of myeloma
cells, there was no significant difference in the expression level of Twist-1 protein between the extramedullary group and
the bone marrow group. The expression level of Twist-1 protein in extramedullary tissue was not related to sex, age, D-S
stage, ISS stage, immunoglobulin type, creatinine and hemoglobin. The expression level of β2-microglobulin in Twist-1
high expression group was significantly higher than that of Twist-1 low expression group. Follow-up findings discovered
that overall survival (OS) of Twist 1 high expression group was significantly lower than that of Twist 1 low expression
group. COX multivariate analysis showed that Twist 1 protein and International Staging System (ISS) stage were
independent risk factors affecting OS for 3 years. The high expression rate of Twist 1 protein in extramedullary lesions of
MM patients with extramedullary lesions is significantly higher than that in bone marrow tissues of patients with
extramedullary lesions. The results suggest that high expression of Twist 1 protein is an independent risk factor affecting the
prognosis of MM patients with extramedullary lesions.
 
Date 2021-10-04T08:59:40Z
2021-10-04T08:59:40Z
2021-10
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58215
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.59(10) [October 2021]