Record Details

Tinospora cordifolia (Willd.) Hook. f. and Thoms. and Arabinogalactan exert chemopreventive action during B(a)P induced pulmonary carcinogenesis: Studies on ultrastructural, molecular and biochemical alterations

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Tinospora cordifolia (Willd.) Hook. f. and Thoms. and Arabinogalactan exert chemopreventive action during B(a)P induced pulmonary carcinogenesis: Studies on ultrastructural, molecular and biochemical alterations
 
Creator Mohan, Vandana
Koul, Ashwani
 
Subject Carcinogen metabolizing enzymes
Chromosomal aberration
Giloy
Guduchi
Micronucleus
Oxidative stress
 
Description 671-687
Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Tc) is a medicinal plant gaining considerable attention owing to its
wide range of pharmacological properties. Though there are ample reports which have documented its biological activity in
various clinical disorders, there is a paucity of information regarding its anticancer activity particularly against
B(a)P induced lung cancer. So, the present study evaluates the chemopreventive potentials of aqueous extract of Tc (Aq.Tc)
and its active component; Arabinogalactan (AG) against Benzo(a)pyrene [B(a)P] induced pulmonary carcinogenesis in
BALB/c mice. B(a)P resulted in significant alteration in carcinogen metabolizing enzymes (CME’s), reduced glutathione
and lipid peroxidation levels. B(a)P also inflicted clastogenic damage, disturbed phospholipid saturation, protein secondary
structures and glycogen content. Altogether these events resulted in the alterations in cellular arrangement of pulmonary
tissue, depicting the outburst of lung carcinogenesis. However, Aq.Tc and AG significantly helped to normalize the
disturbed levels of CME’s and antioxidant machinery. Clastogenic changes, phospholipid saturation, protein secondary
structures and glycogen content were also alleviated with Aq.Tc and AG administration. Additionally, B(a)P+ Aq.Tc and
B(a)P + AG treated groups revealed the classical features of apoptosis. The results suggest that the aquatic extract of gudichi
(Aq.Tc) and Arabinogalactan (AG) modulate various key processes associated with carcinogenesis and can be used as
effective chemopreventive agents.
 
Date 2021-10-04T09:26:27Z
2021-10-04T09:26:27Z
2021-10
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58221
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.59(10) [October 2021]