Record Details

<em>Tinospora cordifolia</em> (Willd.) Hook. f. and Thoms. and Arabinogalactan exert chemopreventive action during B(a)P induced pulmonary carcinogenesis: Studies on ultrastructural, molecular and biochemical alterations

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <em>Tinospora cordifolia</em> (Willd.) Hook. f. and Thoms. and Arabinogalactan exert chemopreventive action during B(a)P induced pulmonary carcinogenesis: Studies on ultrastructural, molecular and biochemical alterations
 
Added Entry - Uncontrolled Name Mohan, Vandana ; Basic Medical Science Block ΙΙ, South Campus, Panjab University, Chandigarh, India
Koul, Ashwani ; Basic Medical Science Block ΙΙ, South Campus, Panjab University, Chandigarh, India
 
Uncontrolled Index Term Carcinogen metabolizing enzymes; Chromosomal aberration; Giloy; Guduchi; Micronucleus; Oxidative stress
 
Summary, etc. <em>Tinospora cordifolia</em> (Willd.) Hook. f. and Thoms. (Tc) is a medicinal plant gaining considerable attention owing to its wide range of pharmacological properties. Though there are ample reports which have documented its biological activity in various clinical disorders, there is a paucity of information regarding its anticancer activity particularly against B(a)P induced lung cancer. So, the present study evaluates the chemopreventive potentials of aqueous extract of Tc (Aq.Tc) and its active component; Arabinogalactan (AG) against Benzo(a)pyrene [B(a)P] induced pulmonary carcinogenesis in BALB/c mice. B(a)P resulted in significant alteration in carcinogen metabolizing enzymes (CME’s), reduced glutathione and lipid peroxidation levels. B(a)P also inflicted clastogenic damage, disturbed phospholipid saturation, protein secondary structures and glycogen content. Altogether these events resulted in the alterations in cellular arrangement of pulmonary tissue, depicting the outburst of lung carcinogenesis. However, Aq.Tc and AG significantly helped to normalize the disturbed levels of CME’s and antioxidant machinery. Clastogenic changes, phospholipid saturation, protein secondary structures and glycogen content were also alleviated with Aq.Tc and AG administration. Additionally, B(a)P+ Aq.Tc and B(a)P + AG treated groups revealed the classical features of apoptosis. The results suggest that the aquatic extract of gudichi (Aq.Tc) and Arabinogalactan (AG) modulate various key processes associated with carcinogenesis and can be used as effective chemopreventive agents.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-10-04 16:22:04
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/55775
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 10 (2021): IJEB [OCTOBER 2021]
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJEB/article/download/55775/465581195