Record Details

<p>Design and synthesis of new quinoline hybrid derivatives and their antimicrobial, antimalarial and antitubercular activities</p><p> </p><br />

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Design and synthesis of new quinoline hybrid derivatives and their antimicrobial, antimalarial and antitubercular activities</p><p> </p><br />
 
Added Entry - Uncontrolled Name Lagdhir, Mohit ; Department of Chemistry, Kadi Sarva Vishwavidyalaya, Gandhinagar 382 024, India
Pandya, Chintan ; Department of Chemistry, Kadi Sarva Vishwavidyalaya, Gandhinagar 382 024, India
Pandya, Aditee ; School of Sciences, P P Savani University, Surat 394 125, India
Vekariya, Rajesh H; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380 009, India
Rajani, Dhanji P; Microcare Laboratory and TRC, Surat 395 003, India
 
Uncontrolled Index Term Molecular hybridization, pharmacophore, quinoline, structural activity relationship (SAR), antimicrobial activity, antimalarial activity, antitubercular activity
 
Summary, etc. <p>All the molecules have been designed on the basis of previously reported active pharmacophores <em>via</em> molecular hybridization. A convenient protocol for the preparation of <em>N</em>-((2-(piperazin-1-yl) quinolin-3-yl)methyl)aniline derivatives <em>via</em> mutli-step synthesis has been described. Spectral analysis using Mass, <sup>1</sup>H and <sup>13</sup>C NMR spectral techniques have been studied in order to confirm the structure of synthesized end molecules. All synthesized compounds have been screened for <em>in vitro </em>antimicrobial, antimalarial and antitubercular activities. Structural activity relationship study (SAR) have also been discussed. Interestingly, target molecules are found to show good to excellent antibacterial, antifungal and antimalarial potency.</p><p> </p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-05 10:39:28
 
Electronic Location and Access http://op.niscair.res.in/index.php/IJCB/article/view/28981
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 7 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/28981/465492407
http://op.niscair.res.in/index.php/IJCB/article/download/28981/465492408
http://op.niscair.res.in/index.php/IJCB/article/download/28981/465492409
http://op.niscair.res.in/index.php/IJCB/article/download/28981/465492410
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.