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Synthesis of isomeric Naphtho furanyl Coumarins as Anti-inflammatory and Analgesic Agents

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Title Statement Synthesis of isomeric Naphtho furanyl Coumarins as Anti-inflammatory and Analgesic Agents
 
Added Entry - Uncontrolled Name Kulkarni, Manohar V; Department of Chemistry Karnatak University Dharwad 580 003 Karnataka
Yaragatti, Naazneen ; P. G. Department of Studies in General Chemistry, Karnatak Science College, Dharwad 580 003, India
Khanapurmath, Netravati ; Department of Studies in Chemistry, Karnatak University, Pavatenagar, Dharwad 580 003, India
 
Uncontrolled Index Term Naphthofuranyl, coumarin, anti-inflammatory, analgesic activity, angular/linear naphthofuranyl coumarins
 
Summary, etc. <p>A two-step synthetic scheme has been employed for the synthesis of 4-naphtho [2, 1-b] furan-2-yl-chromen-2-ones/4-(3-alkoxy-naphtho-[2,3-b]furan-2-yl)-chromen-2-ones(angular/linear naphthofuranyl coumarins). The reactions have been monitored by TLC and structures of the intermediates and the target compounds have been ascertained by IR, NMR and mass spectral data. Both the isomeric naphthofuranyl coumarins have been found to exhibit anti-inflammatory activity comparable to asprin but when tested for analgesic activity, angularly fused naphthofuranyl coumarins show better activity comparable to asprin whereas linear naphthofuranyl coumarins are less active.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-05 10:39:28
 
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http://op.niscair.res.in/index.php/IJCB/article/view/29262
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 7 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/29262/465489972
http://op.niscair.res.in/index.php/IJCB/article/download/29262/465490832
http://op.niscair.res.in/index.php/IJCB/article/download/29262/465490833
 
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