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Effect of Emblica officinalis fruits against metallic-lead induced biochemical and hematological alterations in Wistar rats

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Title Effect of Emblica officinalis fruits against metallic-lead induced biochemical and hematological alterations in Wistar rats
 
Creator Rajkumar, R
Ilango, B
Savidha, R
Vinothkumar, K
Ezhilarasan, D
Sukumar, E
 
Subject Lead toxicity
Indian gooseberry
Animal study
Biochemistry
Hematology
Histopathology
 
Description 451-456
Lead toxicity and related health issues have become global concern due to increased use of lead-based products in the
modern world. Though attempts are being made to tackle this malady through many ways, the use of naturally occurring
materials that are available locally is a subtle approach. In this investigation, the fruits of E. officinalis (EO) were studied for
their potential in overcoming biochemical and hematological alterations caused by metallic lead in rat model. Four groups of
rats, each containing six animals, were considered for the study. Group I served as normal control while to other groups
(II– IV), metallic lead powder (100 ppm/rat) was orally administrated for 30 consecutive days. From day 31, the animals in
groups III and IV were treated with EO in doses of 50 and 100 mg/kg body weight (p. o.), respectively, for the following
seven days. Group II served as lead-treated control. On day 38, the animals in all groups were sacrificed and the blood was
collected and serum separated. The changes in biochemical (aspartate aminotrasferase, alanine aminotrasferase, alkaline
phosphatase, gamma glutamyltrasferase, total cholesterol, triglycerides, urea, creatinine and calcium) and hematological (red
blood cell count, white blood cell count, hemoglobin, packed cell volume and platelet count) parameters were estimated.
Lead treated animals in Group - II showed appreciable changes in hematological and biochemical parameters. Treatment
with EO (50 and 100 mg/kg) significantly restored the changes in the above parameters to near normal values implying that
the fruit of E. officinalis is an effective natural material to overcome widespread lead toxicity. This observation is further
supported by histopathological studies of liver and kidney tissues wherein the distorted architecture, degeneration and other
changes found in lead-treated animals were brought back to near normal stages by the treatment of EO.
 
Date 2021-10-06T06:33:03Z
2021-10-06T06:33:03Z
2021-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/58241
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.58(5) [October 2021]