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<p class="TitleMain">Synthesis and biological activity of 7-(2-(1<em>H</em>-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2<em>H</em>-chromen-2-one</p><br /><p> </p>

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Title Statement <p class="TitleMain">Synthesis and biological activity of 7-(2-(1<em>H</em>-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2<em>H</em>-chromen-2-one</p><br /><p> </p>
 
Added Entry - Uncontrolled Name Bhirud, Jayashri D; School of Chemical Sciences, Moolji Jaitha College, Jalgaon 425 002, India (An autonomous college affiliated to KBCNMU University, Jalgaon)
More, Yogesh B; School of Chemical Sciences, Moolji Jaitha College, Jalgaon 425 002, India (An autonomous college affiliated to KBCNMU University, Jalgaon)
Baviskar, Pankaj D; School of Chemical Sciences, Moolji Jaitha College, Jalgaon 425 002, India (An autonomous college affiliated to KBCNMU University, Jalgaon)
Narkhede, Hemant P; Smt. P. K. Kotecha Mahila Mahavidyalaya, Bhusawal, Dist-Jalgaon 425 305, India
 
Uncontrolled Index Term Coumarin triazole, anti-bacterial, anti-fungal activities, solvent/base pair
 
Summary, etc. <p class="Abstract">Incorporation of other hetero-compounds to parent coumarin increases its effectiveness towards its bioactivity. In view of this finding we have synthesized coumarin triazole derivatives. The key synthon used for this reaction pathway are 7-hydroxy-4-methyl-2<em>H</em>-chromen-2-one. This substituted coumarin has been refluxed with 1-bromo-2-chloroethane in presence of anhydrous K<sub>2</sub>CO<sub>3</sub> to afford 7-(2-chloroethoxy)-4-methyl-2<em>H</em>-chromen-2-one, which has been condensed with triazole to yield 4-methyl coumarin triazole derivative by optimising solvent/base pair. 4-Methyl group of coumarin triazole derivative has been condensed with aromatic aldehydes to afford 7-(2-(1<em>H</em>-1,2,4-triazol-1-yl) ethoxy)-4-(styryl/4-substituted styryl)-2<em>H</em>-chromen-2-one <strong>7a-e</strong>. All the synthesized products are characterized using IR and, <sup>1</sup>H, <sup>13</sup>C NMR, mass spectroscopy and elemental analysis. Final synthesized compounds <strong>7a-e</strong> have been evaluated for their anti-bacterial and anti-fungal activity.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-07 13:24:36
 
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http://op.niscair.res.in/index.php/IJCB/article/view/30157
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 8 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/30157/0
http://op.niscair.res.in/index.php/IJCB/article/download/30157/465492765
http://op.niscair.res.in/index.php/IJCB/article/download/30157/465493265
http://op.niscair.res.in/index.php/IJCB/article/download/30157/465493266
 
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