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<p>Antimicrobial activity of 7,3ʹ,4ʹ-trihydroxyflavonol isolated from <em>Acacia nilotica </em>var. <em>ad stringens</em></p><p> </p>

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Title Statement <p>Antimicrobial activity of 7,3ʹ,4ʹ-trihydroxyflavonol isolated from <em>Acacia nilotica </em>var. <em>ad stringens</em></p><p> </p>
 
Added Entry - Uncontrolled Name Osman, Abubaker Mohammed; King khalid university - KSA
Ahmed, Khalda M; Department of Chemistry, College of Science, King Khalid University, Abha, KSA
Alraih, Al Hafez M; Department of Chemistry, College of Science, King Khalid University, Abha, KSA
Mohamed, Mohamed A; Department of Chemistry, College of Science, Sudan University for Science and Technology, Khartoum, Sudan
Alansari, Mohamed A; Department of Photochemistry and Plant Systematic, National Research Centre, Cairo, Egypt
Abdelrahman, Ayda Y; Department of Chemistry, College of Science, Najran University, Najran, KSA
Hamid, Mohamed E; Department of Microbiology, College of Medicine, King Khalid University, Abha, KSA
king khalid university - Suadia Arabia
 
Uncontrolled Index Term Ethnomedicine, Acaciaspecies, flavonols, spectroscopic analysis, in vitro antimicrobial activity
 
Summary, etc. <p class="Abstract" style="text-align: justify;"><em>Acacia</em> species (Mimosaceae) is widely distributed in tropical and subtropical countries and has a variety of ethnomedicinal uses. There is inadequate laboratory investigation to identify bioactive compounds and therapeutic effect of <em>Acacia nilotica</em> var. <em>ad stringens</em>. This research has been conducted to extract, isolate and identify major compounds from heartwood of <em>Acacia nilotica</em> var. <em>ad stringens</em> and to test them against representative bacteria. Powdered air-dried heartwood of <em>A. nilotica </em>var. <em>ad stringens</em> has been extracted with methanol/water, 4:1 and the extract has been then purified using chromatographic techniques (column and paper chromatography). A pure flavonoid compound has been isolated and the structure has been elucidated based on extensive spectroscopic analysis procedures (IR, UV, <sup>1</sup>H NMR, and mass spectrometery). The isolated compound has then been evaluated for antimicrobial potential against Gram-negative (<em>Escherichia coli</em> and <em>Pseudomonas aeruginosa</em>) and Gram-positive bacteria (<em>Bacillus subtilis</em>, <em>Bacillus cereus</em>, and <em>Staphylococcus aureus</em>) using cup-plate agar diffusion method. The spectroscopic analysis of the isolated compound has led to its identification as 7,3ʹ,4ʹ-trihydroxyflavonol. The compound shows varying antimicrobial responses with high potency against Gram-negative human pathogens. The Gram-positive bacteria which are inhibited are <em>Bacillus cereus, Corynebacterium </em>sp.<em>, Enterococcus faecalis, Staphylococcus aureus , </em>and<em> Streptococcus agalactiae. </em>The Gram-negative bacteria are <em>Acinetobacterbaumannii , Acinetobacter </em>sp.<em> , Escherichia coli, Pseudomonas aeruginosa</em> and yeasts are <em>Candida albicans </em>and<em> Cryptococcus neoformans. </em>The present study has demonstrated that 7,3ʹ,4ʹ-trihydroxyflavonol is an effective antimicrobial compound. If applied in suitable pharmaceutical formulations it could be valuable for treating various bacterial infections or introduced as adjunct treatment along with standard agents.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-07 13:24:36
 
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http://op.niscair.res.in/index.php/IJCB/article/view/29194
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 8 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/29194/465489755
 
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