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<p>An efficient synthesis of Vildagliptin intermediates</p>

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Title Statement <p>An efficient synthesis of Vildagliptin intermediates</p>
 
Added Entry - Uncontrolled Name Hu, Xiangnan ; Department of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
Li, Yufei ; Department of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
Zhang, Li ; Department of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
Wang, Jingyu ; Department of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
Xiang, Peng ; Department of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
Pan, Junyi ; Department of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
Jiang, Lan ; College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400016, P. R. China
Chongqing Science and Technology Commission (cstc2019jscx-msxmX0096); the under-graduate innovative experiment program of Chongqing Medical University (No.201971)
 
Uncontrolled Index Term Vildagliptin, intermediate, 3-amino-1-adamantane alcohol, (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile
 
Summary, etc. <p style="text-align: justify;">Efficient and high yielding methods for the preparation of vildagliptin <strong>1</strong> intermediate of (<em>S</em>)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile <strong>2</strong> and 3-amino-1-adamantane alcohol <strong>3</strong> respectively have been described. (<em>S</em>)-1-(2-Chloroacetyl) pyrrolidine-2-carbonitrile <strong>2</strong> has been synthesized from l-proline <strong>2a</strong> via chloroacetyl chloride, performed with acetonitrile in the presence of sulfuric acid via one-pot reactions. 3-Amino-1-adamantane alcohol <strong>3</strong> has been prepared from amantadine hydrochloride via oxidation by sulfuric acid/nitric acid and boric acid as catalyst, and has been subjected to ethanol extraction. The overall yield is about 95%.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-07 13:24:36
 
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http://op.niscair.res.in/index.php/IJCB/article/view/30478
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 8 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/30478/465493643
http://op.niscair.res.in/index.php/IJCB/article/download/30478/465494296
http://op.niscair.res.in/index.php/IJCB/article/download/30478/465494297
 
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