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<p>Synthesis, molecular docking and biological evaluation of new quinoline analogues as potent anti-breast cancer and antibacterial agents</p><p> </p>

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Title Statement <p>Synthesis, molecular docking and biological evaluation of new quinoline analogues as potent anti-breast cancer and antibacterial agents</p><p> </p>
 
Added Entry - Uncontrolled Name Rathod, Shrimant V.; Department of Chemistry, Bhavan’s Somani and Hazarimal College, Mumbai 400 007, India
Shinde, Kailas W.; Department of Chemistry, Bhavan’s Somani and Hazarimal College, Mumbai 400 007, Department of Chemistry, Wilson College, Mumbai 400 007, India
Kharkar, Prashant S.; Department of Pharmaceutical Quality Assurance, SPTM, NMIMS, Mumbai 400 056, India
Shah, Chetan P.; Department of Pharmaceutical Chemistry, SPTM, NMIMS, Mumbai-400056, India
Aruna, K. ; Department of Microbiology, Wilson College, Mumbai-400007, India
Raut, Darshana A.; Department of Microbiology, Wilson College, Mumbai-400007, India
N.A.
 
Uncontrolled Index Term Antibacterial, anticancer, docking, MDA-MB-231, quinoline analogues, synthesis
 
Summary, etc. <p style="text-align: justify;">A new class of quinoline analogues have been synthesized from isatin through two steps in good yields. They have been further evaluated for their anticancer activity against a breast cancer cell line (MDA-MB-231) and antibacterial activity against Gram-positive bacteria (<em>Staphylococcus aureus 6538p</em> and <em>Bacillus subtilis</em>) and Gram-negative bacteria (<em>Escherichia coli</em> and <em>Pseudomonas aeruginosa</em>). All synthesized compounds have been confirmed by spectral characterization <em>viz</em>. FT-IR, MS, HPLC, <sup>1</sup>H and <sup>13</sup>C NMR. Among them, compound <strong>4h</strong> exhibits promising anti-breast cancer activity whereas compounds <strong>4d</strong>, <strong>4f</strong>, <strong>4h</strong> and <strong>4j </strong>exhibit moderate antibacterial activity against all the tested organisms. Molecular docking analysis demonstrates the interaction of compound <strong>4h </strong>with the active site amino acid of Human Carbonic Anhydrase I, Protein Kinase A and Kinesin Spindle Protein (KSP).</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-14 15:19:06
 
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http://op.niscair.res.in/index.php/IJCB/article/view/31204
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 9 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/31204/465495923
http://op.niscair.res.in/index.php/IJCB/article/download/31204/465495924
http://op.niscair.res.in/index.php/IJCB/article/download/31204/465495925
 
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