Record Details

<p class="TitleMain">Synthesis and screening for antioxidant and cytotoxic activities of novel 2-thioxo-benzo[f]chromeno[2,3-<em>d</em>]pyrimidin-4-ones derived by cetylpyridinium chloride catalyzed multicomponent reactions in aqueous micellar media</p><p> </p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p class="TitleMain">Synthesis and screening for antioxidant and cytotoxic activities of novel 2-thioxo-benzo[f]chromeno[2,3-<em>d</em>]pyrimidin-4-ones derived by cetylpyridinium chloride catalyzed multicomponent reactions in aqueous micellar media</p><p> </p>
 
Added Entry - Uncontrolled Name Laitonjam, Warjeet ; Manipur University
Thiyam, Medhabati ; Department of Chemistry, Manipur University, Canchipur, Imphal 795 003, India
Laitonjam, Warjeet S; Department of Chemistry, Manipur University, Canchipur, Imphal 795 003, India
Haobam, Reena ; Department of Biotechnology, Manipur University, Canchipur, Imphal 795 003, India
CSIR, New Delhi
 
Uncontrolled Index Term Cetylpyridinium chloride, benzochromenopyrimidinones, multicomponent reactions, antioxidant, cytotoxicity
 
Summary, etc. <p class="Abstract" style="text-align: justify;">The cetylpyridinium chloride (CPC) has been used as micellar catalyst in three-component one-pot reaction involving thiobarbituric acids, aromatic aldehydes and β-napthol for synthesizing the novel 2-thioxo-benzo[5,6]chromeno[2,3-<em>d</em>]pyrimidin-4-one derivatives in aqueous media. These 2-thioxo-benzo[5,6]chromeno[2,3-<em>d</em>]pyrimidin-4-one derivatives have been screened for antioxidant and cytotoxic activities. It has been found that 2-thioxo-5-(4-nitrophenyl)-benzo[f]chromeno[2,3-d]pyrimidin-4-one (<strong>4a</strong>) has shown highest scavenging activity<sub> </sub>value to reduce DPPH free radicals, which may be due to the presence of nitro group at <em>para</em>-position. Three compounds, <strong>4a</strong>,<strong> 4b</strong> and <strong>4o</strong> show significant <em>in vitro</em> antitumor activity. The study of the antioxidant and cytotoxic activities reveal that all the compounds show moderate to good activity indicating that the presence of thiouriedo linkage in the pyrimidine nucleus and the chromeno group attached to pyrimidene moiety are responsible for these activities.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-14 15:19:06
 
Electronic Location and Access application/pdf
application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/31602
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 9 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/31602/465497209
http://op.niscair.res.in/index.php/IJCB/article/download/31602/465497210
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.