Record Details

<p>Synthesis of bis chalcones and transformation into bis heterocyclic compounds with expected antimicrobial activity</p><p> </p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Synthesis of bis chalcones and transformation into bis heterocyclic compounds with expected antimicrobial activity</p><p> </p>
 
Added Entry - Uncontrolled Name ghoneim, amira atef
Manoer, Afaf ; Chemistry Department, College of Science, Jouf University, PO Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia
Elbargisy, Rehab M; Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Al Jouf, Kingdom of Saudi Arabia Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
 
Uncontrolled Index Term Synthesis, bis chalcones, heterocyclic, ethylcyanoacetate, cyanopyridine
 
Summary, etc. <p>One-pot synthesis of novel derivatives of bis-chalcones has been achieved by condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives <strong>3a,b</strong> with thioglycolic acid gives compounds <strong>4a,b</strong>. This, when reacted with ethyl cyanoacetate in presence of ammonium acetate gives the corresponding cyanopyridine derivatives <strong>5a,b</strong>. Furthermore, bis-chalcone <strong>3a,b</strong> has been cyclized to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds <strong>7a,b </strong>in good yields. All products have been characterized by IR, <sup>1</sup>H and <sup>13</sup>C NMR, and elemental analysis. The newly synthesised compounds<em> </em>have been screened for anti-bacterial activity.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-14 15:19:06
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/30343
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 9 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.