Record Details

<p>Synthesis and structural confirmation on selective N-alkylation of (<em>Z</em>)-5-((5-chloro-1<em>H</em>-indol-3-l)methylene)thiazolidine-2,4-dione analogues with their molecular docking studies</p><p> </p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Synthesis and structural confirmation on selective N-alkylation of (<em>Z</em>)-5-((5-chloro-1<em>H</em>-indol-3-l)methylene)thiazolidine-2,4-dione analogues with their molecular docking studies</p><p> </p>
 
Added Entry - Uncontrolled Name Prasad, K. J. Rajendra ; Prof. K. J. Rajendra Prasad Department of Chemistry Bharathiar University Coimbatore 641 046 prasad_125@yahoo.com
Sreenatha, Vasappanavara ; Department of Chemistry, Bharathiar University, Coimbatore 641 046, India
 
Uncontrolled Index Term Selective N-alkylation, 2D NMR, Molecular docking studies, ADME studies, T2DM
 
Summary, etc. <p style="text-align: justify;">In the present investigation, a series of novel (<em>Z</em>)-5-((5-chloro-1<em>H</em>-indol-3-yl)methylene)thiazolidine-2,4-dione analogues have been designed and synthesized in good yields with the objective of selective N-alkylation at thiazolidine 2,4-dione ring in competence with indole ring under basic conditions in the presence of aprotic solvent dimethylformamide (DMF). The newly synthesized compounds have been characterized by spectral data (IR, <sup>1</sup>H and <sup>13</sup>C NMR, NOE, NOESY, <sup>1</sup>H-<sup>1</sup>H-COSY and LC-MS). Further, molecular docking and ADME studies have revealed that the newly synthesized compounds have very good docking score against antidiabetic and anti-inflammation activities (PPARy and COX-2) as compared with standard rosiglitazone.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-10-14 15:19:06
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/40828
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 9 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/40828/465527900
http://op.niscair.res.in/index.php/IJCB/article/download/40828/465539563
http://op.niscair.res.in/index.php/IJCB/article/download/40828/465571329
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.