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Gastroprotective effect of n-butanol fractions from Lumnitzera racemosa leaves against indomethacin induced ulcer in Wistar rats

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Title Gastroprotective effect of n-butanol fractions from Lumnitzera racemosa leaves against indomethacin induced ulcer in Wistar rats
 
Creator Darwish, Ahmed Gomaa Gomaa
Samy, Mamdouh Nabil
Mahmoud, Magda Ewies
Matsunami, Katsuyoshi
 
Subject Antiulcer activity
Folk medicine
Gastric ulcers
Inflammation
Mangrove
Mucosal degeneration
Whiteflowered black mangrove
 
Description 785-790
Phytoconstituents from plants serve as a safe replacement for synthetic molecules in drug production. Lumnitzera
racemosa Willd., commonly called white-flowered black mangrove, is used in folk medicine to treat inflammation and other
diseases. Here, we evaluated the antiulcer activity of two fractions (LR-B-4-11 and LR-B-4-12) of n-butanol (n-BuOH)
fractions of L. racemosa leaves at the doses of 50 and 100 mg/kg, body wt. against indomethacin induced gastric mucosal
injury in Wistar rats. The rats were dissected and their stomachs were inspected macroscopically to diagnose hemorrhagic
lesions in the gastric and fundic mucosa. Administration of the fractions at doses of 50 and 100 mg/kg body wt.,
demonstrated a significant reduction in the indomethacin induced gastric erosion when compared to the control. The lower
dose of LR-B-4-11 fraction (50 mg/kg) resulted in better inhibition of indomethacin induced gastric ulcer as compared to the
control. Histological studies of the fundic and gastric mucosa reported that indomethacin led to mucosal degeneration,
ulceration, and migration of numerous inflammatory cells throughout the section. On the other hand, pretreated groups with
n-BuOH fractions demonstrated substantial regeneration of the mucosal layer and significant prevention of hemorrhage and
edema occurrence.
 
Date 2021-11-01T11:28:23Z
2021-11-01T11:28:23Z
2021-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58382
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.59(11) [November 2021]