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Comparative antioxidant and hepatoprotective potential quercetin and corycavidine from Hedyotis corymbosa (L.) Lam. and Solanum xanthocarpum Schrad & Wendl.

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Title Comparative antioxidant and hepatoprotective potential quercetin and corycavidine from Hedyotis corymbosa (L.) Lam. and Solanum xanthocarpum Schrad & Wendl.
 
Creator Gupta, Ramesh Kumar
Swain, Sudhansu Ranjan
Sahoo, Jagannath
Chaudhary, Sachin
Sara, Udaivir Singh
 
Subject Corycavidine
Diamond flower
Flat-top millet grains
Kantakari
Liver disease
Oldenlandia corymbosa
Quercetin
Simvastatin
Wild Eggplant
Yellow berried Nightshade
 
Description 776-784
Liver disease is the major health issues in current era. Antioxidants play the essential role in hepatoprotection by
protecting the hepatic cells against free radicals. Flavonoids and alkaloids are the essential plants bioactive that play the
major role in the antioxidant system. In our project we used diamond flower Hedyotis corymbosa (L.) Lam. and Yellow
berried Nightshade Solanum xanthocarpum Schrad & Wendl., and both plants have major phytoconstituent which acts as
antioxidants. Thus, the aim of the current study validates the isolation, characterization, and determination of in vivo
antioxidant and hepatoprotective consequences of corycavidine and quercetin that were isolated from Diamond flower
Hedyotis corymbosa (L.) Lam. and Yellow berried Nightshade Solanum xanthocarpum Schrad & Wendl.. The study intent
to isolate and identify the antioxidant and hepatoprotective agent from two different plants and compare their
hepatoprotective potential to obtain the most effective liver protective phytoconstituent. Quercetin was isolated from
S. xanthocarpum by column chromatography employing n-butanol: acetic acid: H2O (2:2:6) as a solvent system, however,
corycavidine was isolated from H. corymbosa by column chromatography employing chloroform: methanol: diethylamine
(4:1:2.2) as mobile phase. Structural illustrations were confirmed by UV, FT-IR, 1H-NMR, and 13C-NMR, and mass
spectroscopy. Both the phytoconstituents, corycavidine and quercetin, were explored for their antioxidant potential by
investigating CAT, SOD GSH, and LPO in liver homogenates of experimental rats. Additionally, the in vivo
hepatoprotective effect was examined against simvastatin (20 mg/kg, p.o.), which induced hepatotoxicity in experimental
rodents. The liver protective activity was computed by determining distinct biochemical parameters like SGOT, SGPT,
ALP, bilirubin, total protein, cholesterol and urea along with hematological parameters and histopathological studies. The
results of spectroscopic methods confirmed that the isolated phytochemical constituent from the H. corymbosa is
corycavidine, a benzylisoquinoline alkaloid, however from S. xanthocarpum is quercetin a flavonoid. Both
phytoconstituents significantly (P
 
Date 2021-11-02T10:04:53Z
2021-11-02T10:04:53Z
2021-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58411
 
Language en
 
Publisher CSIR-NIScPR
 
Source IJEB Vol.59(11) [November 2021]