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<p class="MDPI13authornames">Scientific validation of toxicological and anti-hyperglycemic effect of <em>Bambusa tulda</em> leaf</p>

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Title Statement <p class="MDPI13authornames">Scientific validation of toxicological and anti-hyperglycemic effect of <em>Bambusa tulda</em> leaf</p>
 
Added Entry - Uncontrolled Name Dey, Swarna Kamal; Bodoland University, Kokrajhar-783370, Bodoland Territorial Area Districts (BTAD), Assam
Middha, Sushil Kumar; Associate Professor
Usha, Talambedu ; Maharani Lakshmi Ammanni College For Women, Bangalore
Hemavathy, Ekambaram ; Assistant Professor
Foudah, Ahmed Ibrahim; Prince Sattam Bin Abdulaziz University, Alkharj- 11942, SAUDI ARABIA
Kamala, Arunagiri ; Department of Biochemistry,
Samual, Rosa J; Central Animal house Facility,
Yusufoglu, Hasan Soliman; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj- 11942, SAUDI ARABIA
Goyal, Arvind Kumar; Bodoland University
 
Uncontrolled Index Term Anti-diabetic; Anti-hyperglycaemia; Bambusa tulda; Glutathione peroxidase; Superoxide dismutase; Toxicity
 
Summary, etc. Bambusa tulda (Poaceae) is one of the most valuable bamboo species in terms of health-promoting effects. The goal of this research work was to carry out the in-vivo acute toxicity, anti-diabetic and anti-oxidative activities of hydro-methanolic extract of B. tulda leaves. The median lethal dose (LD50) of the hydro-methanolic extract of B. tulda leaves was found to be 6088.13 mg/kg body weight in mice. Supplementing the low (100 mg/kg) and high dose (200 mg/kg) of B. tulda leaf extract showed significant elevation in the endogenous enzymes level of superoxide dismutase (24.81%) and glutathione peroxidase (31.60%) with a decline in malondialdehyde levels (21.90%) when compared to untreated alloxan-induced diabetic control rats. The histopathological assessment of pancreas also showed an increase in β-cells, though not at a significant level. Hence the presence of phyto-constituents substantiates the pharmacological activities of hydro-methanolic extract of B. tulda leaf particularly as a potential candidate for anti-diabetic activity. However, detailed studies are needed to elucidate its exact mechanism of action against diabetes.
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2021-11-04 15:53:28
 
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http://op.niscair.res.in/index.php/IJTK/article/view/30801
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 20, ##issue.no## 4 (2021): Indian Journal of Traditional Knowledge
 
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