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<p>A polyherbal formulation reverses hydrogen peroxide-induced hematological and biochemical aberrations in rats</p>

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Title Statement <p>A polyherbal formulation reverses hydrogen peroxide-induced hematological and biochemical aberrations in rats</p>
 
Added Entry - Uncontrolled Name Ndefo, Joseph Chinedu; University of Nigeria, Nsukka.
OKAGU, INNOCENT UZOCHUKWU; University of Nigeria, Nsukka
Chibuogwu, Christian Chiazor; University of Nigeria, Nsukka
Aham, Emmanuel Chigozie; University of Nigeria, Nsukka
None
 
Uncontrolled Index Term Antioxidant; DRHM®; Hematology; Hepatotoxicity; Hydrogen peroxide; Oxidative damage
 
Summary, etc. DRHM® is a polyherbal formulation [composed of Cymbopogon citratus (17%), Carica papaya leaves (16%), Mangifera indica bark (15%), Moringa oleifera leaves (14%), Citrus limon (12%), Psidium guajava (11%), Zingiber officinale root (9%) and Allium sativum (6%)] that is indicated for many disease conditions and as a detoxifier. In this study, the effects of DRHM® on hydrogen peroxide (3 mL/kg b.w of 5% H2O2, i.p)-induced hematological and biochemical aberrations in rats were evaluated. H2O2 significantly (p&lt;0.05) reduced hemoglobin level, packed cell volume and red blood cell, white blood cell and platelet counts. It elevated the activities of aspartate and alanine aminotransferases and levels of total bilirubin and malondialdehyde. In addition, H2O2 also decreased superoxide dismutase, catalase and glutathione peroxidase activities and reduced glutathione and antioxidant vitamins levels. However, after 14 days of treatment at 1, 2 and 3 mL/kg/d b.w. p.o, DRHM® reversed aberrations in hematological status, enhanced antioxidant status and attenuated lipid peroxidation and hepatic damage induced by H2O2, in a dose-dependent manner comparable to silymarin (100 mg/kg/d. b.w.). These findings suggest that the phytoconstituents in DRHM® might be responsible for these ameliorative effects by boosting antioxidant defense system. DRHM® was tolerable up to 10 mL/kg. b.w.
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2021-11-04 15:53:28
 
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http://op.niscair.res.in/index.php/IJTK/article/view/31447
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 20, ##issue.no## 4 (2021): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/31447/465496717