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Amelioration of experimental rheumatoid arthritis by selected ultra-diluted preparations by down regulating increased expression of TNF-α & IL-6

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Title Amelioration of experimental rheumatoid arthritis by selected ultra-diluted preparations by down regulating increased expression of TNF-α & IL-6
 
Creator Singh, Surender
Karwasra, Ritu
Nayak, Debadatta
Khurana, Anil Kumar
Manchanda, Raj Kumar
 
Subject Histopathology
Homeopathic drugs
Indomethacin
Inflammation
Medorrhinum
Rheumatoid arthritis
 
Description 956-964
The current work explored the inhibitory effect of selected homeopathic drugs, in experimental models of inflammation and CFA-induced arthritis. Twelve groups of animals were made, each containing 6 animals. The selected homeopathic drugs (causticum, calcarea, medorrhinum, mercurius, formica, proteus, silica, sulphur, thuja), placebo and standard drug, Indomethacin. In CFA model, treatment groups and the reference drug were administered daily for a period of 21 days. Dysfunction in joints was evaluated by parameters such as joint diameter, expression of inflammatory markers (TNF-α, IL-6). Findings of the study revealed that on CFA administration, there is a significant (p
 
Date 2021-11-11T09:39:23Z
2021-11-11T09:39:23Z
2021-10
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/58451
 
Language en
 
Relation Int Cl.21: A61K 31/05, A61K 31/352, A61K 31/405, A61K 36/00, A61P 19/02
 
Publisher CSIR-NIScPR, India
 
Source IJTK Vol.20(4) [October 2021]