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Ameliorative effects of Triphala on mucosal damage in rat model of ulcerative colitis

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Title Ameliorative effects of Triphala on mucosal damage in rat model of ulcerative colitis
 
Creator Nariya, Mukeshkumar
Nariya, Pankaj
Ravishankar, Basavaiah
Goswami, Sunita
 
Subject Acetic acid
Antioxidant property
Colonic fluid absorption
Triphala
Ulcerative colitis
 
Description 951-955
In Ayurvedic practice, Triphala is widely used in gastric problems including constipation, large intestinal inflammation
and colitis. The present research was planned to assess the ameliorative effects of Triphala formulations in reducing the
magnitude and severity of ulcerative colitis. Triphala formulations prepared by mixing three fruits, Haritaki (Terminalia
chebula), Bibhitaki (Terminalia belerica) and Amlaki (Emblica officinalis) in different ratios i.e., 1:1:1 (Triphala equal) and
1:2:4 (Triphala unequal) as per classical references. Wistar albino rats were administered with two ml of acetic acid
(4% v/v) in intra-colonic lumen for induction of colitis. The efficacy of Triphala was measured on various parameters
namely, in vivo fluid absorption in tied-off colon, ulcer score and colonic mucosal parameters. The degree of alteration in
colonic fluid transport was significantly reversed by Triphala equal, Triphala unequal and sulphasalzine as standard drug.
Triphala formulations significantly attenuated the nitric oxide (NO), myeloperoxidase (MPO) and lipid peroxidation
(malondialdehyde MDA) levels in mucosa of rat colon. Pre-treatment with Triphala unequal formulation attenuated the
severity of the colonic macroscopic damage score, histologic injury and counteracted the depletion of glutathione and
superoxide dismutase activity hence, reduced the oxidative stress in colonic mucosa. Triphala unequal formulation has better
protective effects. Outcomes of the present study reveal the usefulness of Triphala formulations in attenuating the colonic
inflammation in experimental-induced ulcerative colitis.
 
Date 2021-11-11T09:44:15Z
2021-11-11T09:44:15Z
2021-10
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/58452
 
Language en
 
Relation Int Cl.21: A61K 8/97, A61K 9/00, A61K 36/00, A61K 38/00, A61K 39/395, A61K 45/06, A61P 39/06
 
Publisher CSIR-NIScPR, India
 
Source IJTK Vol.20(4) [October 2021]