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Scientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leaf

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Title Scientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leaf
 
Creator Dey, Swarna Kamal
Middha, Sushil Kumar
Usha, Talambedu
Foudah, Ahmed Ibrahim
Ekambaram, Hemavathy
Kamala, Arunagiri
Samuel, Rosa J
Yusufoglu, Hasan Soliman
Goyal, Arvind Kumar
 
Subject Anti-diabetic
Anti-hyperglycaemia
Bambusa tulda
Glutathione peroxidase
Superoxide dismutase
Toxicity
 
Description 920-926
Bambusa tulda (Poaceae) is one of the most valuable bamboo species in terms of health-promoting effects. The goal of
this research work was to carry out the in-vivo acute toxicity, anti-diabetic and anti-oxidative activities of hydro-methanolic
extract of B. tulda leaves. The median lethal dose (LD50) of the hydro-methanolic extract of B. tulda leaves was found to be
6088.13 mg/kg body weight in mice. Supplementing the low (100 mg/kg) and high dose (200 mg/kg) of B. tulda leaf extract
showed significant elevation in the endogenous enzymes level of superoxide dismutase (24.81%) and glutathione peroxidase
(31.60%) with a decline in malondialdehyde levels (21.90%) when compared to untreated alloxan-induced diabetic control
rats. The histopathological assessment of pancreas also showed an increase in β-cells, though not at a significant level.
Hence the presence of phyto-constituents substantiates the pharmacological activities of hydro-methanolic extract of B.
tulda leaf particularly as a potential candidate for anti-diabetic activity. However, detailed studies are needed to elucidate its
exact mechanism of action against diabetes.
 
Date 2021-11-11T10:12:27Z
2021-11-11T10:12:27Z
2021-10
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/58457
 
Language en
 
Relation Int Cl.21: A61K 39/00, A61K 45/06, A61P 3/10, A61P 7/12, C12N 5/00
 
Publisher CSIR-NIScPR, India
 
Source IJTK Vol.20(4) [October 2021]