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Bioactivity guided fractionation of Icacina trichantha Oliv. (Icacinaceae) tuber for antimalarial activity against Plasmodium berghei infected mice and GC-MS profile of bioactive fraction

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Title Bioactivity guided fractionation of Icacina trichantha Oliv. (Icacinaceae) tuber for antimalarial activity against Plasmodium berghei infected mice and GC-MS profile of bioactive fraction
 
Creator Adaka, I C
Uzor, P F
Nwodo, N J
 
Subject Antimalarial activity
Ethnomedicinal uses
GC-MS analysis
Icacina trichantha
Plasmodium berghei
 
Description 902-912
Aqueous methanol extract of the tuber of Icacina trichantha was prepared using cold maceration and dried in vacuo at 40°C. The extract was purified using solvent-solvent partitioning with n-hexane, dichloromethane, ethyl acetate, n-butanol. n-Hexane fraction was purified using Vacuum Liquid Chromatography, eluting with a gradient of dichloromethane in methanol (9:1, 7:3, 5:5, 0:10, each 500 mL) to obtain four sub-fractions. Acute toxicity study was done using Lorke’s method while in vivo anti-malarial study was carried out using suppressive model. Phytochemical analysis was carried out using standard procedure and most active sub-fraction was subjected to gas chromatography-mass spectroscopy. The extract at doses of 100, 200 and 400 mg/kg caused a significant (p
 
Date 2021-11-11T10:48:52Z
2021-11-11T10:48:52Z
2021-10
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/58459
 
Language en
 
Relation Int Cl.21: A61K 36/00, A61K 36/18, A61K 36/185, A61K 45/06, A61P 33/06
 
Publisher CSIR-NIScPR, India
 
Source IJTK Vol.20(4) [October 2021]