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Spiro-heterocycles: A convenient synthesis and antimicrobial activity of some 3-(5-aryl/aryloxymethyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1',2-thiazolidin-4-ones

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Title Spiro-heterocycles: A convenient synthesis and antimicrobial activity of some 3-(5-aryl/aryloxymethyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1',2-thiazolidin-4-ones
 
Creator Begum, Kahkashan
Ahmad, Akeel
Tiwari, Shailendra
 
Subject Substituted aryl/aryloxymethyl
1,3,4-thiadiazole
spiro-cyclohexane
antimicrobial activity
antifungal activity
 
Description 1490-1495
A new series of novel 3-(5-aryl/aryloxy methyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1'2-thiazolidin-4-ones have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3d, 6c and 6d have shown good antibacterial activity where as compounds 3a, 3b, 6a and 6b have displayed better antifungal activity.
 
Date 2021-11-16T09:10:43Z
2021-11-16T09:10:43Z
2021-11
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58510
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(11) [November 2021]