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Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases

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Title Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases
 
Creator Mallikarjun, G
Raju, A Krishnam
Yadav, J S
 
Subject Benzothiazole
isoxazole
Schiff base
antimicrobial activity
 
Description 1463-1470
A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1H and 13C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d, 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 μg/mL. Further, compounds 12d, 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 μg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.
 
Date 2021-11-16T09:36:25Z
2021-11-16T09:36:25Z
2021-11
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58513
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(11) [November 2021]