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Synthesis, characterization, biological activities of Schiff base metal(II) complexes derived from 4-hydroxy-3,5-dimethoxybenzaldehyde and 3-aminoquinoline

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Title Synthesis, characterization, biological activities of Schiff base metal(II) complexes derived from 4-hydroxy-3,5-dimethoxybenzaldehyde and 3-aminoquinoline
 
Creator Karthik, Somasundaram
Gomathi, Thulasimani
Vedanayaki, Subramaniam
 
Subject Schiff base
Biological activity
Anti-inflammatory
Anti-diabetic
Anticancer
 
Description 1427-1436
A new Schiff base ligand (E)-2,6-dimethoxy-4-((quinolin-3-ylimino)methyl)phenol (HL) and its Cu(II), Co(II), Ni(II)
and Zn(II) metal complexes have been synthesized and characterized by various spectroscopic (UV-visible, IR, NMR and
mass), SEM and magnetic susceptibility measurement. The ligand (HL) have been synthesized by condensation of
4-hydroxy-3,5-dimethoxybenzaldehyde and 3-aminoquinoline. Based on electronic spectral data and magnetic susceptibility
measurement the tetrahedral geometry is proposed for all the complexes. The ligand and metal complexes are screened for
their antimicrobial activities against bacteria (Staphylococcus aureus, Escherichia coli) and antifungal activity against the
fungi (Candida albicans). Further, the ligand and its Cu(II) complex are also screened for anticancer activity on human
breast (MCF7) cancer cell lines by the MTT assay method. Interestingly, Cu(II) complex shows better anticancer activity
than the free Schiff base ligand. The in vitro anti-inflammatory and anti-diabetic activities of the ligand and Cu(II) complex
are studied. The Cu(II) complex show higher inhibition activity than that of the free ligand.
 
Date 2021-11-16T10:36:17Z
2021-11-16T10:36:17Z
2021-11
 
Type Article
 
Identifier 0975-1017 (Online); 0971-4588 (Print)
http://nopr.niscair.res.in/handle/123456789/58517
 
Language en
 
Publisher CSIR-NIScPR
 
Source IJC-A Vol.60A(11) [November 2021]