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Microwave synthesis, characterization and biological activities of transition metal complexes with novel SNSN donor Schiff base ligand

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Title Microwave synthesis, characterization and biological activities of transition metal complexes with novel SNSN donor Schiff base ligand
 
Creator Devi, P R Sagunthala
David, S Theodore
Joel, C
Bennie, R Biju
Abraham, S Daniel
 
Subject Schiff base
Microwave synthesis
Antibacterial studies
BSA
Cytotoxicity
 
Description 1416-1426
A novel Schiff base (E)-N-(pyridine-2-yl)thiophen-2-ylmethylene)hydrazine carbothioamide (L), has been synthesised
by the condensation of thiophen-2-carbaldehyde and 4-(pyridin-2-yl)-thiosemicarbazide, using solvent free microwave
synthesis. The Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base are also prepared. They are characterised by
elemental analysis, EI-mass spectrum, 1H &13C-NMR spectrum, FTIR, UV-vis spectra, magnetic, EPR spectra and thermal
analysis. The “SNSN” donor ligand binds the metal ion in tetradentate mode through thiophenyl and thioenolic sulphur
atoms and imino and pyridine nitrogen atoms. The electronic spectra along with magnetic measurements demonstrate
tetrahedral geometry for Co(II), Ni(II) and Zn(II) complexes, and square planar geometry for Cu(II) complex. All the
complexes are found to be thermally stable from thermogravimetric studies. The complexes show enhanced antibacterial
activity than the ligand against various bacterial strains. The BSA binding activity of the complexes shows that the affinity
for binding is greater towards copper complex. The cytotoxicity of the ligand and its complexes are tested on HT29 colon
cancer cells using MTT assay.
 
Date 2021-11-16T10:45:15Z
2021-11-16T10:45:15Z
2021-11
 
Type Article
 
Identifier 0975-1017 (Online); 0971-4588 (Print)
http://nopr.niscair.res.in/handle/123456789/58518
 
Language en
 
Publisher CSIR-NIScPR
 
Source IJC-A Vol.60A(11) [November 2021]