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<p>Synthesis, antimicrobial activity and cytotoxicity of 2-substituted benzimidazole incorporated with thiazole</p>
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| Authentication Code |
dc |
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| Title Statement |
<p>Synthesis, antimicrobial activity and cytotoxicity of 2-substituted benzimidazole incorporated with thiazole</p> |
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| Added Entry - Uncontrolled Name |
Fultariya, Chirag Rameshbhai; Shree M P Shah Arts and Science College, Bus Stand Road, Surendranagar 363 001, India Harsora, Jalpa Praffulbhai; Shree M P Shah Arts and Science College, Bus Stand Road, Surendranagar 363 001, India Charotar University of Science and Technology |
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| Uncontrolled Index Term |
2-Substituted benzimidazole, thiazole, antibacterial activity, antifungal activity, cytotoxicity |
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| Summary, etc. |
<p style="text-align: justify;">Two new series 2-(2-(1-(1-methyl-1<em>H</em>-benzo[<em>d</em>]imidazol-2-yl)ethylidene)hydrazinyl)-4-(aryl)thiazoles <strong>3a-k</strong> and 2-(2-(1-(1-methyl-1<em>H</em>-benzo[<em>d</em>]imidazol-2-yl)ethyl)hydrazinyl)-4-(aryl)thiazoles<strong> 4a-k </strong>encompassing benzimidazole incorporated with thiazole have been synthesized using rational approach. These thiazole derivatives <strong>3a-k </strong>have been reduced at the site of formation of Schiff base (>CH=N-) to obtain final compounds <strong>4a-k</strong>. Compounds <strong>3a-k</strong> and <strong>4a-k</strong> have been screened for their <em>in vitro</em> antibacterial and antifungal actions against four strains each. Among the screened compounds, <strong>3d, 3e, 3f, 3g, 3j, 3k, 4d, 4e, 4f</strong> and <strong>4k</strong> have emerged as highly effective antibacterial agents, while compounds <strong>3d, 3e, 3f, 3k </strong>and <strong>4k</strong> have come out as most potent antifungal molecules. Comparison of outcomes of antibacterial and antifungal screening of compounds <strong>3a-k</strong> and <strong>4a-k </strong>directed that antimicrobial potential of unreduced derivatives <strong>3a-k </strong>is higher than reduced derivatives <strong>4a-k</strong>. SAR study reveals that presence of halogen (-F, -Cl, -Br) substituents is accountable for significant antimicrobial potential. Also the results of preliminary MTT cytotoxicity assay on HeLa cells indicates that antimicrobial activity of <strong>3e, 3f, 3g, 3j, 3k, 4e, 4f</strong> and <strong>4k </strong>is accompanied by low extent of cytotoxic concentrations.</p><p style="text-align: justify;"> </p> |
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| Publication, Distribution, Etc. |
Indian Journal of Chemistry -Section B (IJC-B) 2021-11-18 10:12:23 |
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| Electronic Location and Access |
application/pdf application/pdf http://op.niscair.res.in/index.php/IJCB/article/view/32889 |
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| Data Source Entry |
Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 11 (2021): Indian Journal of Chemistry- Section-B, (IJCB) |
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| Language Note |
en |
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| Nonspecific Relationship Entry |
http://op.niscair.res.in/index.php/IJCB/article/download/32889/465501938 http://op.niscair.res.in/index.php/IJCB/article/download/32889/465511014 http://op.niscair.res.in/index.php/IJCB/article/download/32889/465511015 |
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