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<p>Synthesis, characterization and biological evaluation of some 2-arylbenzoxazole acetic acid derivatives as potential anticancer agents</p>

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Title Statement <p>Synthesis, characterization and biological evaluation of some 2-arylbenzoxazole acetic acid derivatives as potential anticancer agents</p>
 
Added Entry - Uncontrolled Name Jilani, Jamal Abdellatif; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
Abualassal, Qais Ibrahim; Department of Applied Pharmaceutical Science and Clinical Pharmacy, Faculty of Pharmacy, Al-Isra University, Amman, Jordan
Assaf, Areej Mashhour; Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan
Abushmeis, Reham Mahmoud; Department of Chemistry, Faculty of Science, Al-Balqa Applied University, Al Salt, Jordan
 
Uncontrolled Index Term Cytotoxicity, arylbenzoxazoles, MCF-7, structure-activity relationships, lead tetraacetate
 
Summary, etc. <p class="Abstract" style="text-align: justify;"><span lang="EN-GB">A series of 2-arylbenzoxazole compounds possessing a cytotoxic activity as potential anticancer agents has been synthesised. Oxidative coupling of benzaldehyde with <em>o</em>-aminophenol utilizing lead tetraacetate approach has been used to realize the synthesis of compounds <strong>1</strong>-<strong>11</strong>. The cytotoxicity of <strong>1</strong>-<strong>11</strong> have been screened against breast cancer cell line MCF-7 and human colon cancer cell line HCT-116 utilizing doxorubicin as reference drug. Among these compounds, 2-(3-benzyloxyphenyl)benzoxazole-5-acetic acid <strong>5</strong> and 2-(4-methoxyphenyl)benzoxazol-5-acetic acid <strong>10</strong>, are found to be promising cytotoxic compounds against MCF-7 cell line. In addition, this study shows that the presence of acetic acid group at position 5 of benzoxazole nucleus enhances the activity. Moreover, it is noticed that the presence of oxygen atom directly linked to the phenyl substituent improves activity. The results offer a new benzoxazole based template to design and develop novel antineoplastic agents.</span></p><p class="Default" style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-11-18 10:12:23
 
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http://op.niscair.res.in/index.php/IJCB/article/view/33016
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 11 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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