Record Details

<p style="text-align: justify;">Antioxidant potential of crude extract, flavonoid-rich fractions, and a new compound from the seeds of<em> Cordia dichotoma</em></p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;">Antioxidant potential of crude extract, flavonoid-rich fractions, and a new compound from the seeds of<em> Cordia dichotoma</em></p>
 
Added Entry - Uncontrolled Name Usmani, Shazia ; Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, Uttar Pradesh, India
Hussain, Arshad ; Harsha Institute of Pharmacy, Abdul Kalam Technical University, Lucknow 226203, India
Wahab, Shadma ; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia
Kushwaha, Poonam ; Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, Uttar Pradesh, India
Khatoon, Shabana ; Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, Uttar Pradesh, India
Arif, Muhammad ; Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, Uttar Pradesh, India
Prakash, Om ; Goel Institute of Pharmacy and Sciences, Faizabad Road, Lucknow 226001, Uttar Pradesh, India
Kamal, Mehnaz ; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia
 
Uncontrolled Index Term Antioxidant activity; Cordia dichotoma; DPPH; Flavonoids; Phytochemical; Thin-layer chromatography.
 
Summary, etc. <p style="text-align: justify;">The current study assessed the antioxidant activity of methanolic extract and different fractions of the seeds of <em>Cordia dichotoma</em> by 2,2-diphenyl-2-picrylhydrazyl hydrate method. Phytochemical screening of <em>C. dichotoma</em> seed extract was done using thin-layer chromatography technique and phytochemical methods. The percentage yield of secondary metabolites like alkaloids and saponins was also determined. The methanolic extract was subjected to isolation by Column Chromatography. Phytochemical screening revealed the presence of significant amounts of phenols and flavonoids in the extract. TLC analysis confirmed the presence of phytoconstituents with the application of derivatizing agents like aluminium chloride and anisaldehyde. Total phenolic and flavonoid contents obtained were 37.7 and 32.16% w/w, respectively. The crude seed extract of <em>C. dichotoma</em> showed inhibition at all concentrations in a dose-dependent manner. Maximum scavenging activity was exhibited by the methanolic extract with a low IC<sub>50</sub> value. A new compound named Cordioside was also isolated from the same extract. The phytochemical screening of the seed extract showed the presence of rich amounts of phenolic compounds and flavonoids, which may be acting as the key factors responsible for the antioxidant activity. The results revealed that methanolic extract and the aqueous fraction of <em>C. dichotoma</em> seed possess a significant antioxidant activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-11-23 17:02:01
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/40712
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 3 (2021): September 2021
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.