Record Details

Evaluation of the anti-ulcer activity of seeds<em> </em>of <em>Syzyzium cumini </em>on experimental animal models

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement Evaluation of the anti-ulcer activity of seeds<em> </em>of <em>Syzyzium cumini </em>on experimental animal models
 
Added Entry - Uncontrolled Name Kar, Durga Madhab; Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India
Nayak, Puravi ; Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India
Jena, Rasmita ; Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India
Pattanaik, Sovan ; Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India
Rath, Diptirani ; Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India
Nil
 
Uncontrolled Index Term Natural plant research, Ethnobotany, Anti-ulcer drug
Anti-ulcer activity; Pyloric ligation; Ranitidine; Stress-induced; Syzyzium cumini; Ulcer index.
 
Summary, etc. <p style="text-align: justify;"><em>Syzyzium cumini</em> (Myrtaceae) is an evergreen tropical tree mostly found in South East Asia. Extracts of fruits and seeds are extensively used in the treatment of diabetes. Other folkloric uses include treatment of cold, cough, fever, skin problem and genitourinary tract ulcer. The present study evaluated the anti-ulcer activity of the seeds of <em>S. cumini</em> against different ulcer models in rats. The anti-ulcer activity of the methanol extract and ethyl acetate fraction of methanol extract of <em>S. cumini </em>seed was evaluated in ethanol, pylorus ligation, Aspirin + pylorus ligation and stress-induced gastric ulcer model. The study biomarkers used were gastric volume, pH, ulcer index and free acidity. The extract and fraction at the dose level of 200 mg/kg caused a significant (<em>P </em>&lt;0.05) reduction in the ulcer index, free acidity while there was an increase in the pH value of the test in comparison to the solvent control group. Experimentally, it was observed that animals who received ethyl acetate fraction had relatively improved protection of gastric ulcer as demonstrated by different biomarkers. The present study showed that the ethyl acetate fraction of methanol extract of <em>S. cumini </em>seed possesses potential anti-ulcer activity. This may be due to a linear relationship between the antioxidant value of the seeds as reported earlier by several authors due to rich in phenolic compounds, which in turn is responsible for mucosal cytoprotection of the stomach and hence, participate in the enhancement of mucosal defence mechanism.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-11-23 17:02:01
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/34662
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 3 (2021): September 2021
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/34662/0
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.