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<p style="text-align: justify;">Acute toxicity and anti-dyslipidemic activity of <em>Arogyavardhini</em> compound in fructose-induced dyslipidemia in albino rats</p>

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Title Statement <p style="text-align: justify;">Acute toxicity and anti-dyslipidemic activity of <em>Arogyavardhini</em> compound in fructose-induced dyslipidemia in albino rats</p>
 
Added Entry - Uncontrolled Name Padhar, Bharatkumar C; PG Department of Kayachikitsa, National Institute of Ayurveda, Jaipur 302002, Rajasthan, India
Dave, Alankruta R; Department of Kayachikitsa, Institute of Teaching and Research in Ayurveda, Jamnagar 361008, Gujarat, India
Nariya, Mukeshkumar ; Pharmacology Laboratory, Institute of Teaching and Research in Ayurveda, Jamnagar 361008, Gujarat, India
 
Uncontrolled Index Term Multidisciplinary especially of applied nature;Disease control measures;value added products and utilization of plants in broader sense
Acute toxicity; Antidyslipidemic activity; Arogyavardhini compound; Fructose; Metabolic syndrome.
 
Summary, etc. <p style="text-align: justify;">Metabolic syndrome is a co-occurrence of obesity, insulin resistance, hypertension, and dyslipidemia caused by improper diet and lifestyle.<em> Arogyavardhini </em>compound (AVC) contains an equal quantity of <em>Arogyavardhini rasa</em> and <em>Lasuna</em> powder. In clinical practice, <em>Arogyavardhini Rasa</em> is well known for its antidyslipidemic and weight lowering effect. Therefore, the present experimental study was designed to evaluate the safety of AVC on acute administration and anti-dyslipidemic activity in albino rats. An acute oral toxicity study for AVC was carried out by following OECD 425 guidelines. The anti-dyslipidemic activity was carried out against fructose-induced dyslipidemia in albino rats. No mortality and toxicity were observed and gross behaviours of all the albino rats were found normal during the experimental period of 14 days in the acute toxicity study. Fructose significantly increased blood sugar, triglycerides, SGPT, and alkaline phosphatase levels in albino rats in comparison to the control group. AVC treated group produced a decrease in serum triglyceride, transaminases, and alkaline phosphatase, which suggest that the drug has potential as anti-dyslipidemic and may be protective for degenerative changes produced by fructose in the liver, kidney, and heart of albino rats. From the present study it is concluded that AVC is safe up to an oral dose of 2000 mg/kg in albino rats and has exhibited a protective role in fructose-induced dyslipidemia in albino rats, hence may be useful in metabolic syndrome.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2021-11-23 17:02:01
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/27911
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 3 (2021): September 2021
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/27911/465486104
http://op.niscair.res.in/index.php/IJNPR/article/download/27911/465486105
http://op.niscair.res.in/index.php/IJNPR/article/download/27911/465486106
http://op.niscair.res.in/index.php/IJNPR/article/download/27911/465486107
 
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