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Evaluation of health status of Oreochromis niloticus (L.) based on brain optic tectum morphopathology

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Title Evaluation of health status of Oreochromis niloticus (L.) based on brain optic tectum morphopathology
 
Creator Samanta, Palas
Ghosh, Apurba Ratan
 
Subject Adverse outcome pathways
Almix and Excel Mera 71
Brain
Herbicides
Neurotoxicity
Nile tilapia
 
Description 877-883
Oreochromis niloticus (L.) health status was evaluated based on brain optic tectum morphopathology. O. niloticus was
exposed to sub-lethal Almix (66.67 mg/L) and Excel Mera 71 (17.2 mg/L) concentrations for 30 d. Results revealed that
herbicides exposure caused different morphological changes in brain optic tectum. Almix treatment showed comparatively
higher morphological changes compared with Excel Mera 71. The mean assessment value (MAV) showed significantly
higher (p < 0.0001) value in Almix (4.36±0.09) and Excel Mera 71 (3.60±0.09) exposure, in comparison with control fish
(0.09±0.02). Stratum album centrale (SAC) and stratum periventriculare (SPV) were most affected layer compared with
others. The observed morphological alterations revealed impaired visual, sensory and motor functions, which ultimately
alters brain physiology. In particularly, the existence of necrosis in neural cells, loss of Nissl substances, gliosis and vacuole
formations under Almix and Excel Mera 71 exposure indicated neurotoxic nature of these herbicides. However, higher
prevalence under Almix treatment indicated higher neurotoxic potential than Excel Mera 71. Therefore, the results presented
here are highly significant to toxicologist considering its neurotoxic property. Finally, further studies are needed to explore
detailed mode of action of neurotoxicity for adverse outcome pathways (AOP) development at molecular level.
 
Date 2021-12-02T06:29:54Z
2021-12-02T06:29:54Z
2021-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58568
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.59(12) [December 2021]